Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families.

ABSTRACT: Tourette's Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is not well understood. In this study, we combined the segregation information in 13 TD multiplex families with high-throughput sequencing and genotyping to identify genes associated with TD. Using whole-exome sequencing and genotyping array data, we identified both small and large genetic variants within the individuals. We then combined multiple types of evidence to prioritize candidate genes for TD, including variant segregation pattern, variant function prediction, candidate gene expression, protein-protein interaction network, candidate genes f

SUBMITTER: Cao X 

PROVIDER: S-EPMC8501157 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature