Interactions between PDA-associated polymorphisms and genetic ancestry alter ductus arteriosus gene expression.

ABSTRACT:

Background

DNA polymorphisms in PTGIS and TFAP2B have been identified as risk factors for patent ductus arteriosus (PDA) in a population composed of preterm infants with European genetic ancestry but not in more genetically diverse populations.

Goal

To determine if the effects of TFAP2B and PTGIS polymorphisms on ductus arteriosus (DA) gene expression differ based on genetic ancestry.

Methods

DA from 273 human second trimester fetuses were genotyped for TFAP2B and PTGIS polymorphisms and for polymorphisms distributing along genetic ancestry lines. RT-PCR was used to measure the RNA expression of 49 candidate genes involved with DA closure.

Results

Seventeen percent of the DA analyzed were of European ancestry. In multivariable regression analyses we found consi

SUBMITTER: Clyman RI 

PROVIDER: S-EPMC8501158 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature