The ATTACH™ program and immune cell gene expression profiles in mothers and children: A pilot randomized controlled trial.

ABSTRACT:

Background

Children exposed to adversity and toxic stress are at increased risk for poor health across the lifespan, possibly through alterations to immune pathways. Parenting interventions could buffer the effect of adversity on child immune activity. The purpose of this study was to test whether mothers and children who were randomly assigned to a parenting intervention (ATTACH™) had healthier post-intervention immune cell gene expression patterns, as indexed by the Conserved Transcriptional Response to Adversity (CTRA), compared with mothers and children in a wait-list control group.

Methods

A sample of 20 mother-child dyads were recruited from a domestic violence shelter in Calgary, AB, Canada. The ATTACH™ program is a 10-week psycho-educational intervention that fosters

SUBMITTER: Ross KM 

PROVIDER: S-EPMC8501501 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature