Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma.

ABSTRACT:

Background

DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signaling effector stimulator of interferon genes (STING) present a novel role in anti-tumor immunity. Recently, the combination of cGAS-STING agonists and immunotherapy achieved promising results in some tumor types. The correlation between cGAS-STING signaling pathway and the tumor immune microenvironment in patients with oral squamous cell carcinoma (OSCC) is unclear.

Methods

We utilized RNA sequencing and clinical data of OSCC patients from the TCGA database to investigate the correlation between cGAS-STING signaling pathway and the tumor immune microenvironment. Six cGAS-STING related genes were obtained from previous studies to establish the enrichment score of cGAS-STING pathway. The dif

SUBMITTER: Zhu C 

PROVIDER: S-EPMC8501566 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature