TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus.

ABSTRACT: The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer's disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal damage. The tumor necrosis factor (TNF) superfamily of cytokines are involved in many systemic chronic inflammatory and degenerative conditions and are amongst the key mediators of neuroinflammation. TNF binds to the TNFR1 and TNFR2 receptors to activate diverse cellular responses that can be either neuroprotective or neurodegenerative. In particular, TNF can induce programmed necrosis or necroptosis in an inflammatory environment. Although activation of necroptosis has recently been demonstrated in the AD brain, its significance in AD neuron loss and the role of TNF signaling is uncl

SUBMITTER: Jayaraman A 

PROVIDER: S-EPMC8501605 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature