Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors.

ABSTRACT:

Background

Genetic alterations are common in non-small cell lung cancer (NSCLC), and DNA mutations and translocations are targets for therapy. Copy number aberrations occur frequently in NSCLC tumors and may influence gene expression and further alter signaling pathways. In this study we aimed to characterize the genomic architecture of NSCLC tumors and to identify genomic differences between tumors stratified by histology and mutation status. Furthermore, we sought to integrate DNA copy number data with mRNA expression to find genes with expression putatively regulated by copy number aberrations and the oncogenic pathways associated with these affected genes.

Methods

Copy number data were obtained from 190 resected early-stage NSCLC tumors and gene expression data were avai

SUBMITTER: Bjaanæs MM 

PROVIDER: S-EPMC8501630 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature