FAM83H and Nectin1 expression are related with survival and relapse of bladder urothelial carcinoma patients.

ABSTRACT:

Background

FAM83H was originally reported to be essential for dental enamel formation. However, FAM83H has recently been implicated in tumorigenesis and tumor progression. Analysis of a publicly available gene expression database revealed a significant correlation between FAM83H and Nectin1 mRNA expression and bladder urothelial carcinoma (BUC). Therefore, we investigated the association between FAM83H and Nectin1 expression levels and the survival and recurrence of BUC in BUC patients using a tissue microarray.

Methods

We performed immunohistochemical staining of FAM83H and Nectin1 in 165 human BUC tissue sections, and analyzed the prognostic significance of FAM83H and Nectin1 expression.

Results

Both FAM83H and Nectin1 were mainly expressed in the cytoplasm, and the

SUBMITTER: Ahn AR 

PROVIDER: S-EPMC8501681 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature