A systematic review of common genetic variation and biological pathways in autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent deficits in social communication and interaction. Common genetic variation appears to play a key role in the development of this condition. In this systematic review, we describe the relationship between genetic variations and autism. We created a gene dataset of the genes involved in the pathogenesis of autism and performed an over-representation analysis to evaluate the biological functions and molecular pathways that may explain the associations between these variants and the development of ASD.

Results

177 studies and a gene set composed of 139 were included in this qualitative systematic review. Enriched pathways in the over-representation analysis using the K

SUBMITTER: Rodriguez-Gomez DA 

PROVIDER: S-EPMC8501721 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature