Circuit-specific enteric glia regulate intestinal motor neurocircuits.

ABSTRACT: Glia in the central nervous system exert precise spatial and temporal regulation over neural circuitry on a synapse-specific basis, but it is unclear if peripheral glia share this exquisite capacity to sense and modulate circuit activity. In the enteric nervous system (ENS), glia control gastrointestinal motility through bidirectional communication with surrounding neurons. We combined glial chemogenetics with genetically encoded calcium indicators expressed in enteric neurons and glia to study network-level activity in the intact myenteric plexus of the proximal colon. Stimulation of neural fiber tracts projecting in aboral, oral, and circumferential directions activated distinct populations of enteric glia. The majority of glia responded to both oral and aboral stimulation and circumfere

SUBMITTER: Ahmadzai MM 

PROVIDER: S-EPMC8501758 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature