A Novel Pyroptosis-Related Gene Signature for Early-Stage Lung Squamous Cell Carcinoma.

ABSTRACT:

Background

Diagnosis of early stage lung squamous cell carcinoma (LUSC) has improved; however, a comprehensive analysis of prognostic signatures is needed.

Purpose

To identify, establish, and validate a signature model based on pyroptosis-related genes for prognostic predictions of early stage LUSC.

Patients and methods

Two independent cohorts were included. RNA-seq transcriptome data from patients with early stage LUSC were obtained from The Cancer Genome Atlas (TCGA) database. Thirty-three pyroptosis-related genes were analyzed between early stage LUSC and normal lung tissues. Cox regression analysis, random survival forest, and least absolute shrinkage and selection operator algorithms established a three-gene signature. Kaplan-Meier survival and receiver-operating

SUBMITTER: Li X 

PROVIDER: S-EPMC8502038 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature