Ontology highlight
ABSTRACT:
SUBMITTER: LaRocca TJ
PROVIDER: S-EPMC8502211 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
LaRocca Thomas J TJ Cavalier Alyssa N AN Roberts Christine M CM Lemieux Maddie R MR Ramesh Pooja P Garcia Micklaus A MA Link Christopher D CD
Neurobiology of disease 20210828
The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily selected functions of Aβ are incompletely understood. Here, we report that nanomolar concentrations of Aβ act synergistically with known cytokines to promote pro-inflammatory activation in primary human astrocytes (a cell type increasingly implicated in brain aging and AD). Using transcriptomics (RNA-seq), we sh ...[more]