Serum circulating miRNA-342-3p as a potential diagnostic biomarker in parathyroid carcinomas: A pilot study.

ABSTRACT:

Objective

To compare the serum miRNA expression profiles between patients with benign and malignant parathyroid tumours.

Background

Despite recent advances in molecular biology, a histological tissue biopsy is still the method of choice used to diagnose most cancers. The preoperative cytology is not an applicable method for diagnosis of parathyroid cancer (PC); therefore, huge interest exists in terms of finding alternative methodologies to seek specific cancer biomarkers.

Design

A retrospective cross-sectional study.

Patients and methods

Serum samples of patients with PC (n = 13) and parathyroid adenoma (PA) (n = 11), age (p = .999) and sex (p = .999) were matched and examined via the simultaneous comparative expression analysis of 754 microRNAs (miRNAs). The

SUBMITTER: Krupinova J 

PROVIDER: S-EPMC8502227 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature