Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae.

ABSTRACT:

Background

Telomerase-negative cells have limited proliferation potential. In these cells, telomeres shorten until they reach a critical length and induce a permanently arrested state. This process called replicative senescence is associated with genomic instability and participates in tissue and organismal ageing. Experimental data using single-cell approaches in the budding yeast model organism show that telomerase-negative cells often experience abnormally long cell cycles, which can be followed by cell cycles of normal duration, before reaching the terminal senescent state. These series of non-terminal cell cycle arrests contribute to the heterogeneity of senescence and likely magnify its genomic instability. Due to their apparent stochastic nature, investigating the dynamics a

SUBMITTER: Martin H 

PROVIDER: S-EPMC8502270 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature