Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer's continuum.

ABSTRACT:

Background

Given that tau accumulation, not amyloid-β (Aβ) burden, is more closely connected with cognitive impairment in Alzheimer's disease (AD), a detailed understanding of the tau-related characteristics of cognitive function is critical in both clinical and research settings. We investigated the association between phosphorylated tau (p-Tau) level and cognitive impairment across the AD continuum and the mediating role of medial temporal lobe (MTL) atrophy. We also developed a prediction model for abnormal tau accumulation.

Methods

We included participants from the Gwangju Alzheimer's Disease and Related Dementia Cohort in Korea, who completed cerebrospinal fluid analysis and clinical evaluation, and corresponded to one of three groups according to the biomarkers of A an

SUBMITTER: Seo EH 

PROVIDER: S-EPMC8502282 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature