Simvastatin induced ferroptosis for triple-negative breast cancer therapy.

ABSTRACT: Triple-negative breast cancer (TNBC), a management of aggressive breast cancer, remains an unmet medical challenge. Although a wave of efforts had spurred to design novel therapeutic method of TNBC, unpredictable prognosis with lacking effective therapeutic targets along with the resistance to apoptosis seriously limited survival benefits. Ferroptosis is a non-apoptotic form of cell death that is induced by excessive lipid peroxidation, which provide an innovative way to combat cancer. Emerging evidence suggests that ferroptosis plays an important role in the treatment of TNBC cells. Herein, a novel ferroptosis nanomedicine was prepared by loading simvastatin (SIM), a ferroptosis drug, into zwitterionic polymer coated magnetic nanoparticles (Fe₃O₄@PCBMA) to improve th

SUBMITTER: Yao X 

PROVIDER: S-EPMC8502296 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature