ι-Carrageenan nanocomposites for enhanced stability and oral bioavailability of curcumin.

ABSTRACT:

Background

Carrageenan (CRN), a polygalactan consisting of 15 to 40% ester sulfate, is used in oral controlled-release technology due to its viscosity and large molecular weight. Curcumin (Cur) is a highly potent antioxidant and anti-inflammatory agent against various diseases, such as tumors, liver disease, rheumatism, and Alzheimer's disease. Although Cur shows excellent effects in the body, it has major problems, such as poor solubility and low bioavailability in water.

Method

Nanocomposites containing Cur were developed by emulsion technique. Cur@CRN was characterized through the viscosity measurement, size analysis, stability test, and loading efficiency. Antioxidant effects was analyzed with DPPH reagent, and anti-inflammatory effects was analyzed by NFkB/IkBr signalin

SUBMITTER: Lee JY 

PROVIDER: S-EPMC8502325 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature