Associations between YKL-40 and markers of disease severity and death in patients with necrotizing soft-tissue infection.

ABSTRACT:

Background

Necrotizing soft-tissue infection (NSTI) is a severe and fast-progressing bacterial infection. Prognostic biomarkers may provide valuable information in treatment guidance and decision-making, but none have provided sufficient robustness to have a clinical impact. YKL-40 may reflect the ongoing pathological inflammatory processes more accurately than traditional biomarkers as it is secreted by the activated immune cells, but its prognostic yields in NSTI remains unknown. For this purpose, we investigated the association between plasma YKL-40 and 30-day mortality in patients with NSTI, and assessed its value as a marker of disease severity.

Methods

We determined plasma YKL-40 levels in patients with NSTI (n = 161) and age-sex matched controls (n = 65) upon admissio

SUBMITTER: Hedetoft M 

PROVIDER: S-EPMC8502346 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature