Analysis of the myeloid-derived suppressor cells and annexin A1 in multibacillary leprosy and reactional episodes.

ABSTRACT:

Background

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Patients have distinct clinical forms, and the host´s immunological response regulate those manifestations. In this work, the presence of the myeloid-derived suppressor cell and the regulatory protein annexin A1 is described in patients with multibacillary leprosy and with type 1 and 2 reactions.

Methods

Patients were submitted to skin biopsy for histopathological analysis to obtain a bacilloscopic index. Immunofluorescence was used to detect myeloid-derived suppressor cells and annexin A1.

Results

The data demonstrated that the presence of granulocytic and monocytic myeloid-derived suppressor cells in leprosy patients. A high number of monocytic myeloid-derived suppressor cells were ob

SUBMITTER: da Silva SF 

PROVIDER: S-EPMC8502368 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature