Methods for the inclusion of real-world evidence in network meta-analysis.

ABSTRACT:

Background

Network Meta-Analysis (NMA) is a key component of submissions to reimbursement agencies world-wide, especially when there is limited direct head-to-head evidence for multiple technologies from randomised controlled trials (RCTs). Many NMAs include only data from RCTs. However, real-world evidence (RWE) is also becoming widely recognised as a valuable source of clinical data. This study aims to investigate methods for the inclusion of RWE in NMA and its impact on the level of uncertainty around the effectiveness estimates, with particular interest in effectiveness of fingolimod.

Methods

A range of methods for inclusion of RWE in evidence synthesis were investigated by applying them to an illustrative example in relapsing remitting multiple sclerosis (RRMS). A liter

SUBMITTER: Jenkins DA 

PROVIDER: S-EPMC8502389 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature