Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer.

ABSTRACT:

Background

Pyroptosis is a form of programmed cell death triggered by inflammasomes. However, the roles of pyroptosis-related genes in thyroid cancer (THCA) remain still unclear.

Objective

This study aimed to construct a pyroptosis-related signature that could effectively predict THCA prognosis and survival.

Methods

A LASSO Cox regression analysis was performed to build a prognostic model based on the expression profile of each pyroptosis-related gene. The predictive value of the prognostic model was validated in the internal cohort.

Results

A pyroptosis-related signature consisting of four genes was constructed to predict THCA prognosis and all patients were classified into high- and low-risk groups. Patients with a high-risk score had a poorer overall surviva

SUBMITTER: Wu P 

PROVIDER: S-EPMC8502398 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature