Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies.

ABSTRACT:

Background

Integrating functional annotations into SNP-set association studies has been proven a powerful analysis strategy. Statistical methods for such integration have been developed for continuous and binary phenotypes; however, the SNP-set integrative approaches for time-to-event or survival outcomes are lacking.

Methods

We here propose IEHC, an integrative eQTL (expression quantitative trait loci) hierarchical Cox regression, for SNP-set based survival association analysis by modeling effect sizes of genetic variants as a function of eQTL via a hierarchical manner. Three p-values combination tests are developed to examine the joint effects of eQTL and genetic variants after a novel decorrelated modification of statistics for the two components. An omnibus test (IEHC-AC

SUBMITTER: Lu H 

PROVIDER: S-EPMC8502405 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature