Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.

ABSTRACT:

Background

According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety behaviors. However, the psychobiotic effects and mechanisms of PS128 in Alzheimer's disease (AD) remain to be explored.

Objectives

The goal of the current study was to evaluate the beneficial effects of PS128 and to further elucidate its mechanism in AD mice.

Methods

PS128 (10¹⁰ colony-forming unit (CFU)/ml) was administered via oral gavage (o.g.) to 6-month-old male wild-type B6 and 3 × Tg-AD mice (harboring the PS1M146V, APPswe and TauP30IL transgenes) that received an intracerebroventricular

SUBMITTER: Huang HJ 

PROVIDER: S-EPMC8502419 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature