Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones.

ABSTRACT:

Aims

Sex differences have been consistently identified in cardiac physiology and incidence of cardiac disease. However, the underlying biological causes for the differences remain unclear. We sought to characterize the cardiac non-myocyte cellular landscape in female and male hearts to determine whether cellular proportion of the heart is sex-dependent and whether endocrine factors modulate the cardiac cell proportions.

Methods and results

Utilizing high-dimensional flow cytometry and immunofluorescence imaging, we found significant sex-specific differences in cellular composition of the heart in adult and juvenile mice, that develops postnatally. Removal of systemic gonadal hormones by gonadectomy results in rapid sex-specific changes in cardiac non-myocyte cellular proport

SUBMITTER: Squiers GT 

PROVIDER: S-EPMC8502469 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature