A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children.

ABSTRACT:

Background

Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19). The reasons underlying these different outcomes remain unknown.

Methods

We analyzed three different cohorts: children with acute infection (n=550), convalescent children (n=138), and MIS-C (multisystem inflammatory syndrome in children, n=42). IgG and IgM antibodies to the spike protein of SARS-CoV-2, serum-neutralizing activity, plasma cytokine levels, and the frequency of circulating Follicular T helper cells (cTfh) and plasmablasts were analyzed by conventional methods.

Findings

Fifty-eight percent of the children in t

SUBMITTER: Sananez I 

PROVIDER: S-EPMC8502533 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature