Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling.

ABSTRACT:

Objective

Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines. The conversion of white into brown-like adipocytes (browning) may increase energy expenditure and revert the positive energy balance that underlies obesity. Although different gp130 cytokines and their downstream targets were shown to regulate expression of the key browning marker uncoupling protein 1 (Ucp1), it remains largely unknown how this contributes to the development and maintenance of obesity. Herein, we aim to study the role of gp130 cytokine signaling in white adipose tissue (WAT) browning in the obese state.

Methods

Protein and gene expression levels of UCP1 and other thermogenic markers were assessed in a subcutane

SUBMITTER: van Krieken PP 

PROVIDER: S-EPMC8502775 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature