Effect of a day-trip to altitude (2500 m) on exercise performance in pulmonary hypertension: randomised crossover trial.

ABSTRACT:

Question addressed by the study

To investigate exercise performance and hypoxia-related health effects in patients with pulmonary hypertension (PH) during a high-altitude sojourn.

Patients and methods

In a randomised crossover trial in stable (same therapy for >4 weeks) patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) with resting arterial oxygen tension (P _aO2 ) ≥7.3 kPa, we compared symptom-limited constant work-rate exercise test (CWRET) cycling time during a day-trip to 2500 m versus 470 m. Further outcomes were symptoms, oxygenation and echocardiography. For safety, patients with sustained hypoxaemia at altitude (peripheral oxygen saturation <80% for >30 min or <75% for >15 m

SUBMITTER: Schneider SR 

PROVIDER: S-EPMC8502941 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature