Lower Limb Deformity and Gait Deviations Among Adolescents and Adults With X-Linked Hypophosphatemia.

ABSTRACT:

Background

X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by lower limb deformity, gait and joint problems, and pain. Hence, quality of life is substantially impaired. This study aimed to assess lower limb deformity, specific radiographic changes, and gait deviations among adolescents and adults with XLH.

Design

Data on laboratory examination and gait analysis results were analyzed retrospectively. Deformities, osteoarthritis, pseudofractures, and enthesopathies on lower limb radiographs were investigated. Gait analysis findings were compared between the XLH group and the control group comprising healthy adults.

Patients and controls

Radiographic outcomes were assessed retrospectively in 43 patients with XLH (28 female, 15 male). Gait analysi

SUBMITTER: Mindler GT 

PROVIDER: S-EPMC8503556 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature