Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway.

ABSTRACT:

Background and purpose

Deep brain stimulation (DBS) is the most common surgical treatment for essential tremor (ET), yet there is variation in outcome and stimulation targets. This study seeks to consolidate proposed stimulation "sweet spots," as well as assess the value of structural connectivity in predicting treatment outcomes.

Materials and methods

Ninety-seven ET individuals with unilateral thalamic DBS were retrospectively included. Using normative brain connectomes, structural connectivity measures were correlated with the percentage improvement in contralateral tremor, based on the Fahn-Tolosa-Marin tremor rating scale (TRS), after parameter optimization (range 3.1-12.9 months) using a leave-one-out cross-validation in 83 individuals. The predictive feature map was u

SUBMITTER: Middlebrooks EH 

PROVIDER: S-EPMC8503569 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature