Extracellular Matrix Characterization in Gastric Cancer Helps to Predict Prognosis and Chemotherapy Response.

ABSTRACT: The extracellular matrix (ECM) plays a central role in the formation of the tumor microenvironment. The deposition of the ECM is associated with poor prognosis in a variety of tumors. Aberrant ECM deposition could undermine the effect of chemotherapy and immunotherapy. However, there is no systematic analysis on the relationship between the ECM and prognosis or chemotherapy effect. In the present study, we applied the gene set variation analysis (GSVA) algorithm to score 2199 canonical pathways in 2125 cases of probe or sequencing data and identified the core matrisome as the driving factor in gastric cancer progression. We classified gastric cancer samples into three clusters according to the composition of the ECM and evaluated clinical and multi-omics characterization of ECM phenotypes.

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8503650 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature