A comparison of automated atrophy measures across the frontotemporal dementia spectrum: Implications for trials.

ABSTRACT:

Background

Frontotemporal dementia (FTD) is a common cause of young onset dementia, and whilst there are currently no treatments, there are several promising candidates in development and early phase trials. Comprehensive investigations of neuroimaging markers of disease progression across the full spectrum of FTD disorders are lacking and urgently needed to facilitate these trials.

Objective

To investigate the comparative performance of multiple automated segmentation and registration pipelines used to quantify longitudinal whole-brain atrophy across the clinical, genetic and pathological subgroups of FTD, in order to inform upcoming trials about suitable neuroimaging-based endpoints.

Methods

Seventeen fully automated techniques for extracting whole-brain atrophy mea

SUBMITTER: Gordon E 

PROVIDER: S-EPMC8503665 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature