ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.

ABSTRACT:

Background

The polymorphism Arg16 in β₂ -adrenergic receptor (ADRB2) gene has been associated with an increased risk of exacerbations in asthmatic children treated with long-acting β₂ -agonists (LABA). However, it remains unclear whether this increased risk is mainly attributed to this single variant or the combined effect of the haplotypes of polymorphisms at codons 16 and 27.

Objective

We assessed whether the haplotype analysis could explain the association between the polymorphisms at codons 16 (Arg16Gly) and 27 (Gln27Glu) in ADRB2 and risk of asthma exacerbations in patients treated with inhaled corticosteroids (ICS) plus LABA.

Methods

The study was undertaken using data from 10 independent studies (n = 5903) participating in the multi-ethnic

SUBMITTER: Karimi L 

PROVIDER: S-EPMC8503671 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature