A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.

ABSTRACT: Aberrant connectivity of large-scale brain networks has been observed among individuals with alcohol use disorders (AUDs) as well as in those at risk, suggesting deficits in neural communication between brain regions in the liability to develop AUD. Electroencephalographical (EEG) coherence, which measures the degree of synchrony between brain regions, may be a useful measure of connectivity patterns in neural networks for studying the genetics of AUD. In 8810 individuals (6644 of European and 2166 of African ancestry) from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a Multi-Trait Analyses of genome-wide association studies (MTAG) on parietal resting-state theta (3-7 Hz) EEG coherence, which previously have been associated with AUD. We also examined developme

SUBMITTER: Meyers JL 

PROVIDER: S-EPMC8503860 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature