Impact of prenatal exome sequencing for fetal genetic diagnosis on maternal psychological outcomes and decisional conflict in a prospective cohort.

ABSTRACT:

Purpose

To evaluate associations between prenatal trio exome sequencing (trio-ES) and psychological outcomes among women with an anomalous pregnancy.

Methods

Trio-ES study enrolling patients with major fetal anomaly and normal microarray. Women completed self-reported measures and free response interviews at two timepoints: pre- (1) and post- (2) sequencing. Pre-sequencing responses were compared with post-sequencing responses; post-sequencing responses were stratified by women who received trio-ES results that may explain fetal findings, secondary findings (medically actionable or couples with heterozygous variants for the same recessive disorder), or negative results.

Results

One hundred fifteen trios were enrolled. Of those, 41/115 (35.7%) received results from tri

SUBMITTER: Talati AN 

PROVIDER: S-EPMC8503913 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature