Identification of nut protein-derived peptides against SARS-CoV-2 spike protein and main protease.

ABSTRACT: Recently, an outbreak of a novel coronavirus disease (COVID-19) has reached pandemic proportions, and there is an urgent need to develop nutritional supplements to assist with prevention, treatment, and recovery. In this study, SARS-CoV-2 inhibitory peptides were screened from nut proteins in silico, and binding affinities of the peptides to the SARS-CoV-2 main protease (M^pro) and the spike protein receptor-binding domain (RBD) were evaluated. Peptide NDQF from peanuts and peptide ASGCGDC from almonds were found to have a strong binding affinity for both targets of the coronavirus. The binding sites of the NDQF and ASGCGDC peptides are highly consistent with the M^pro inhibitor N3. In addition, NDQF and ASGCGDC exhibited an effective binding affinity for amino acid res

SUBMITTER: Zhao W 

PROVIDER: S-EPMC8503973 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature