Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide.

ABSTRACT:

Background

Inhalation of fungal spores is a strong risk factor for severe asthma and experimentally leads to development of airway mycosis and asthma-like disease in mice. However, in addition to fungal spores, humans are simultaneously exposed to other inflammatory agents such as lipopolysaccharide (LPS), with uncertain relevance to disease expression. To determine how high dose inhalation of LPS influences the expression of allergic airway disease induced by the allergenic mold Aspergillus niger (A. niger).

Methods

C57BL/6J mice were intranasally challenged with the viable spores of A. niger with and without 1 μg of LPS over two weeks. Changes in airway hyperreactivity, airway and lung inflammatory cell recruitment, antigen-specific immunoglobulins, and histopathology were

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC8503997 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature