Ecology impacts the decrease of Spirochaetes and Prevotella in the fecal gut microbiota of urban humans.

ABSTRACT: Compared to the huge microbial diversity in most mammals, human gut microbiomes have lost diversity while becoming specialized for animal-based diets - especially compared to chimps, their genetically closest ancestors. The lowered microbial diversity within the gut of westernized populations has also been associated with different kinds of chronic inflammatory diseases in humans. To further deepen our knowledge on phylogenetic and ecologic impacts on human health and fitness, we established the herein presented biobank as well as its comprehensive microbiota analysis. In total, 368 stool samples from 38 different animal species, including Homo sapiens, belonging to four diverse mammalian orders were collected at seven different locations and analyzed by 16S rRNA gene amplicon sequencing.

SUBMITTER: Thingholm LB 

PROVIDER: S-EPMC8504008 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature