Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and cirrhosis. NAFLD is mediated by changes in lipid metabolism and known risk factors include obesity, metabolic syndrome, and diabetes. The aim of this study was to better understand differences in the lipid composition of individuals with NAFLD compared to controls, by performing direct infusion lipidomics on serum biospecimens from a cohort study of adults in Mexico.

Methods

A nested case-control study was conducted with a sample of 98 NAFLD cases and 100 healthy controls who are participating in an on-going, longitudinal study in Mexico. NAFLD cases were clinically confirmed using elevated liver enzyme tests and liver ultrasound or liver ultrasound elastography, after excludi

SUBMITTER: Flores YN 

PROVIDER: S-EPMC8504048 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature