Radiotherapy Response Assessment of Multiple Myeloma: A Dual-Energy CT Approach With Virtual Non-Calcium Images.

ABSTRACT:

Background

Life expectancy of patients with multiple myeloma (MM) has increased over the past decades, underlining the importance of local tumor control and avoidance of dose-dependent side effects of palliative radiotherapy (RT). Virtual noncalcium (VNCa) imaging from dual-energy computed tomography (DECT) has been suggested to estimate cellularity and metabolic activity of lytic bone lesions (LBLs) in MM.

Objective

To explore the feasibility of RT response monitoring with DECT-derived VNCa attenuation measurements in MM.

Methods

Thirty-three patients with 85 LBLs that had been irradiated and 85 paired non-irradiated LBLs from the same patients were included in this retrospective study. Irradiated and non-irradiated LBLs were measured by circular regions of interest

SUBMITTER: Fervers P 

PROVIDER: S-EPMC8504158 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature