Alterations to the urinary metabolome following semi-controlled short exposures to ultrafine particles at a major airport.

ABSTRACT:

Background

Inflammation, oxidative stress and reduced cardiopulmonary function following exposure to ultrafine particles (UFP) from airports has been reported but the biological pathways underlying these toxicological endpoints remain to be explored. Urinary metabolomics offers a robust method by which changes in cellular pathway activity can be characterised following environmental exposures.

Objective

We assessed the impact of short-term exposures to UFP from different sources at a major airport on the human urinary metabolome.

Methods

21 healthy, non-smoking volunteers (aged 19-27 years) were repeatedly (2-5 visits) exposed for 5h to ambient air at Amsterdam Airport Schiphol, while performing intermittent, moderate exercise. Pre- to-post exposure changes in urinary

SUBMITTER: Selley L 

PROVIDER: S-EPMC8504201 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature