Kinetics of polymerase chain reaction positivity in patients with Clostridioides difficile infection.

ABSTRACT:

Background

Polymerase chain reaction (PCR) is a sensitive test for diagnosing Clostridioides difficile infection (CDI) and could remain positive following resolution of CDI. The kinetics of PCR positivity following antibiotics for CDI is unknown. We studied this and whether it predicted CDI recurrence.

Methods

Adults with CDI from October 2009 to May 2017 were included. Serial stool samples within 60 days of treatment were collected. Recurrent CDI was defined as diarrhea after interim symptom resolution with positive stool PCR within 56 or 90 days of treatment completion. Contingency table analysis was used to assess the risk of recurrence.

Results

Fifty patients were included [median age: 51 (range = 20-86) years, 66% women]. Treatment given was metronidazole,

SUBMITTER: Saha S 

PROVIDER: S-EPMC8504224 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature