Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review.

ABSTRACT:

Background

Bipolar disorder (BD) is a cyclic mood disorder characterised by alternating episodes of mania/hypomania and depression interspersed with euthymic periods. Lamotrigine (LTG) demonstrated some mood improvement in patients treated for epilepsy, leading to clinical studies in patients with BD and its eventual introduction as maintenance therapy for the prevention of depressive relapse in euthymic patients. Most current clinical guidelines include LTG as a recommended treatment option for the maintenance phase in adult BD, consistent with its global licencing status.

Aims

To review the evidence for the efficacy and safety of LTG in the treatment of all phases of BD.

Methods

PubMed was searched for double-blind, randomised, placebo-controlled trials using the ke

SUBMITTER: Besag FMC 

PROVIDER: S-EPMC8504232 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature