Differential induction of innate memory in porcine monocytes by β-glucan or bacillus Calmette-Guerin.

ABSTRACT: Innate immunomodulation via induction of innate memory is one mechanism to alter the host's innate immune response to reduce or prevent disease. Microbial products modulate innate responses with immediate and lasting effects. Innate memory is characterized by enhanced (training) or depressed (tolerance) innate immune responses, including pro-inflammatory cytokine production, to secondary exposure following a priming event. To investigate the ability of β-glucans and bacillus Calmette-Guerin to induce innate training or tolerance in pig cells, porcine monocytes were cultured with priming agonist (β-glucans or bacillus Calmette-Guerin) then re-stimulated 5 d later with a heterologous microbial agonist to determine induction of innate memory. Priming with β-glucan from Saccharomyces cerevi

SUBMITTER: Byrne KA 

PROVIDER: S-EPMC8504267 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature