Standardization of Aspergillus IgG diagnostic cutoff in Nigerians.

ABSTRACT:

Background and objectives

Commercial Aspergillus IgG antibody assays have become pivotal in the current diagnosis of chronic pulmonary aspergillosis (CPA). However, diagnostic cutoffs have been found to vary from manufactures' recommendations in different settings. This study aimed to establish the Aspergillus IgG reference range among Nigerians and determine a diagnostic cutoff for CPA.

Methods

Sera from 519 prospectively recruited healthy blood donors and 39 previously confirmed cases of CPA were analysed for Aspergillus IgG levels using the Bordier test kit (Bordier Affinity Products SA, Crissier, Switzerland). Accuracy versus cutoff profile and receiver operating characteristics (ROC) curve were analysed for both CPA cases and controls using t

SUBMITTER: Oladele RO 

PROVIDER: S-EPMC8504277 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature