A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury.

ABSTRACT: Epidural stimulation of the spinal cord is a promising technique for the recovery of motor function after spinal cord injury. The key challenges within the reconstruction of motor function for paralyzed limbs are the precise control of sites and parameters of stimulation. To activate lower-limb muscles precisely by epidural spinal cord stimulation, we proposed a high-density, flexible electrode array. We determined the regions of motor function that were activated upon epidural stimulation of the spinal cord in a rat model with complete spinal cord, which was established by a transection method. For evaluating the effect of stimulation, the evoked potentials were recorded from bilateral lower-limb muscles, including the vastus lateralis, semitendinosus, tibialis anterior, and medial gastro

SUBMITTER: Mao GW 

PROVIDER: S-EPMC8504402 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature