Frequency selective neuronal modulation triggers spreading depolarizations in the rat endothelin-1 model of stroke.

ABSTRACT: Ischemia is one of the most common causes of acquired brain injury. Central to its noxious sequelae are spreading depolarizations (SDs), waves of persistent depolarizations which start at the location of the flow obstruction and expand outwards leading to excitotoxic damage. The majority of acute stage of stroke studies to date have focused on the phenomenology of SDs and their association with brain damage. In the current work, we investigated the role of peri-injection zone pyramidal neurons in triggering SDs by optogenetic stimulation in an endothelin-1 rat model of focal ischemia. Our concurrent two photon fluorescence microscopy data and local field potential recordings indicated that a ≥ 60% drop in cortical arteriolar red blood cell velocity was associated with SDs at the ET-1 injec

SUBMITTER: Bazzigaluppi P 

PROVIDER: S-EPMC8504421 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature