Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC8504519 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Zhou Wei W Chen Luan L Jiang Bixuan B Sun Yidan Y Li Mo M Wu Hao H Zhang Na N Sun Xiaofang X Qin Shengying S
CNS neuroscience & therapeutics 20211101 11
In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the ...[more]