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Large-scale whole-exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder.


ABSTRACT: In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the pathophysiology of MDD.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC8504519 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Large-scale whole-exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder.

Zhou Wei W   Chen Luan L   Jiang Bixuan B   Sun Yidan Y   Li Mo M   Wu Hao H   Zhang Na N   Sun Xiaofang X   Qin Shengying S  

CNS neuroscience & therapeutics 20211101 11


In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the  ...[more]

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