Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative disease, and its pathogenesis is unclear. Previous studies mainly focus on the lesions of substantia nigra (SN) and striatum (Str) in PD. However, lesions are not limited. The olfactory bulb (OB), subventricular zone (SVZ), and hippocampus (Hippo) are also affected in PD.

Aim

To reveal gene expression changes in the five brain regions (OB, SVZ, Str, SN, and Hippo), and to look for potential candidate genes and pathways that may be correlated with the pathogenesis of PD.

Materials and methods

We established control group and 6-hydroxydopamine (6-OHDA) PD model group, and detected gene expressions in the five brain regions using RNA-seq and real-time quantitative polymerase chain reaction (RT-qPCR). We further a

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC8504527 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature