ASHLEYS: automated quality control for single-cell Strand-seq data.

ABSTRACT:

Summary

Single-cell DNA template strand sequencing (Strand-seq) enables chromosome length haplotype phasing, construction of phased assemblies, mapping sister-chromatid exchange events and structural variant discovery. The initial quality control of potentially thousands of single-cell libraries is still done manually by domain experts. ASHLEYS automates this tedious task, delivers near-expert performance and labels even large data sets in seconds.

Availability and implementation

github.com/friendsofstrandseq/ashleys-qc, MIT license.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Eimer C 

PROVIDER: S-EPMC8504637 | biostudies-literature |

REPOSITORIES: biostudies-literature