Heterogeneous Longitudinal Antibody Responses to Covid-19 mRNA Vaccination.

ABSTRACT:

Background

Public health measures to stem the coronavirus disease 2019 (COVID-19) pandemic are challenged by social, economic, health status, and cultural disparities that facilitate disease transmission and amplify its severity. Prior pre-clinical biomedical technologic advances in nucleic acid-based vaccination enabled unprecedented speed of conceptualization, development, production, and widespread distribution of mRNA vaccines that target SARS-CoV-2's Spike (S) protein.

Design

Twenty-five female and male volunteer fulltime employees at the Providence VA Medical Center participated in this study to examine longitudinal antibody responses to the Moderna mRNA-1273 vaccine. IgM-S and IgG-S were measured in serum using the Abbott IgM-S-Qualitative and IgG2-S-Quantitative chem

SUBMITTER: de la Monte SM 

PROVIDER: S-EPMC8504644 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature