Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients.

ABSTRACT:

Objective

To explore the hypermethylated long non-coding (lnc)RNAs involved in bladder carcinogenesis and prognosis.

Methods

Reduced representation bisulfite sequencing and RNA sequencing were performed on five paired tumor and adjacent normal tissue samples from bladder cancer patients. The differentially methylated regions around transcription start sites and differentially expressed genes, including lncRNAs, were analyzed. Correlations between DNA methylation modifications and the expression of lncRNAs were examined. Survival analysis was surveyed on the GEPIA web server.

Results

We identified 19,560 hypomethylated and 68,781 hypermethylated differentially methylated regions around transcription start sites in bladder cancer tissues. In total, 2321 differentially e

SUBMITTER: Luo J 

PROVIDER: S-EPMC8504649 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature